Liverpool’s hopes of a top-four spot were dented as Southampton dramatically snatched victory at St Mary’s.
Liverpool had looked in command after Philippe Coutinho and Daniel Sturridge scored in a five-minute period.
Sadio Mane missed a penalty just after the break following Martin Skrtel’s foul on Graziano Pelle, but made amends soon after with a smart finish.
Pelle’s curling shot restored parity in the 83rd minute, before Mane pounced to seize all three points for his side.
Liverpool pressed forward to try and force a final twist, but a speculative penalty shout for a push on Christian Benteke was all they could muster.